Acute Flaccid Myelitis (AFM)

• Case Definition
• Disease Report Form
  • Patient summary form
  • Instructions for completing the patient summary form
• Guidance
  • Reporting patients under investigation for AFM
  • Specimen Collection instructions
  • AFM Clinician Guidance memo

Anaplasmosis - Updated March 2024

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2
• Surveillance Algorithm

Anthrax

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Babesiosis

• Case Definition
• Disease Report Form
• LHD Disease Investigation Steps
• Surveillance Algorithm

Botulism

• Botulism, foodborne
• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2

• Botulism, infant (intestinal)
• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2

• Botulism, wound
• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2

• Botulism, other
• Case Definition

Brucellosis

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Campylobacter infection

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

**NEW** Candida auris (C. auris)

• Case Definition
• Communicable Disease Reporting Form

Carbapenemase-Producing Organisms (CPO)

• CPO Investigation Steps - Updated August 2024
• Case Definition
• Algorithm for new cases - Updated November 2024
  • CPO Guidance for LHD Staff - August 2024
• Resources:
  • Preventing MDROs | HAIs | CDC
  • MDRO Containment Strategy | HAIs | CDC
  • MDROs Toolkit for Long-Term Care Facilities – Updated April 2024
  • NC DPH Interfacility Transfer Form
• Communicable Disease Reporting Form

Chancroid

• See Sexually Transmitted Disease Protocols
• Case Definition
• Disease Report Form

Chikungunya

• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Chlamydial infection – laboratory confirmed

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form

Cholera

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Creutzfeldt-Jakob Disease

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Cryptosporidiosis

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Cyclosporiasis

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• Contact CDB to obtain Cyclosporiasis Surveillance Case Report Form
• REDCap Cyclospora Reporting

Dengue

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Diphtheria

• See Vaccine Preventable Manuals (CDC)
• Case Definition - Updated June 2019
• Disease Report Form
• Part 1
• Part 2
• Diphtheria Investigation Overview

E.coli infection- shiga toxin producing

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition - Updated January 2018
• Disease Report Form
• Part 1
• Part 2

Ehrlichiosis (E.chaffeensis, E. ewiingii, E. muris eauclairensis and unspecified Ehrlichiosis) - Updated March 2024

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• Surveillance Algorithm

Encephalitis/Meningitis, Arboviral

• Encephalitis, arboviral, EEE
• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2
• Encephalitis, arboviral, LAC
• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2
• Encephalitis, arboviral, other
• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2

• Encephalitis, arboviral, WNV
• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2

Foodborne poisoning

• Foodborne poisoning: ciguatera
• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2
• Foodborne poisoning: mushroom
• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2
• Foodborne poisoning: scombroid fish
• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2

Foodborne

• Foodborne: c. perfringens
• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2
• Foodborne: other/unknown
• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2
• Foodborne: staphylococcal
• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2

Gonorrhea

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition - Updated September 2017
• Disease Report Form

Granuloma inguinale

• See Sexually Transmitted Disease Protocols
• Case Definition
• Disease Report Form

Haemophilus influenzae, invasive disease

• Disease Notes
• LHD Disease Investigation Steps
• Standing Order Template
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• H. influenzae Investigation Overview

Hantavirus Infection, Non-Hantavirus Pulmonary Syndrome

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Hantavirus Pulmonary Syndrome (HPS)

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Hemolytic-uremic syndrome (HUS)

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Hemorrhagic fever virus infection

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• Ebola Resources

Hepatitis A

• Standing Order Template - Updated January 2019
• Case Definition - Updated January 2019
• Disease Report Form
• Part 1
• Part 2
• Hepatitis A Supplemental Case Report Form (Word)
• Hepatitis A Resources

Hepatitis B, acute

• Disease Notes
• LHD Disease Investigation Steps
• See Vaccine Preventable Manuals (CDC)
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• HBV Algorithm (PDF)
• HBV Case Definition Algorithm (PDF)
• HBV Serology Algorithm (PDF)

Hepatitis B, carriage, chronic

• Disease Notes
• LHD Disease Investigation Steps
• See Vaccine Preventable Manuals (CDC)
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• HBV Case Definition Algorithm (PDF)
• HBV Serology Algorithm (PDF)

Hepatitis B, perinatally acquired

• See Vaccine Preventable Manuals (CDC)
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Hepatitis C, acute

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition - Updated January 2020
• Disease Report Form
• Part 1
• Part 2
• Control Measures for Persons Infected with Hepatitis C

Hepatitis C, perinatally acquired

• Disease Report Form
  • Part 2

HIV/AIDS

• See Sexually Transmitted Disease Protocols
• Case Definition
• Disease Report Form

Influenza, NOVEL virus infection

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2 - Updated June 2024
• Novel Flu Resources

Influenza, adult death (>= 18 years of age)

• Case Definition
• Disease Report Form
• Part 1
• Part 2

Influenza, pediatric death (< 18 years of age)

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Legionellosis

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• Legionellosis Prevention and Response Toolkit
• Sentinel Case Investigation
• Outbreak Investigation

Leprosy (Hansen's Disease)

• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Leptospirosis

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Listeriosis

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Case Definition Infographic
• Disease Report Form
• Part 1
• Part 2
• Supplemental CDC Listeria Initiative Form

Lyme Disease

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• Surveillance Algorithm

Lymphogranuloma venereum

• See Sexually Transmitted Disease Protocols
• Case Definition
• Disease Report Form

Malaria

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Measles (Rubeola)

• See Vaccine Preventable Manuals (CDC)
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• Measles Resources

Meningitis, pneumococcal

• Case Definition
• Disease Report Form
• Part 1
• Part 2
• Pneumococcal Meningitis Investigation Overview

Meningococcal disease, invasive

• Case Definition
• Standing Order Templates
  • Ciprofloxacin
  • Ceftriaxone (Rocephin)
  • Rifampin
• Disease Report Form
• Part 1
• Part 2
• Invasive Meningococcal Disease Investigation Overview

Middle East Respiratory Syndrome (MERS)

• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2 (contact CDB)

Mpox

• Mpox Investigation Overview
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2
• Mpox Resources

Mumps

• VPD Surveillance Manual (CDC)
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2
• Mumps Resources

Non-gonococcal urethritis

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form

Ophthalmia neonatorum

• See Sexually Transmitted Disease Protocols
• Disease Report Form

Paratyphoid Fever (Salmonella enterica serotypes Paratyphi A, B [tartrate negative], and C)

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• Typhoid and Paratyphoid Fever Surveillance Report Form

Pertussis (whooping cough)

• See Vaccine Preventable Manuals (CDC)
• Case Definition - Updated January 2020
• Disease Report Form
• Part 1
• Part 2
• Pertussis Resources

PID (chlamydial/gonococcal)

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form

Plague

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Psittacosis

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Poliomyelitis, paralytic

• See Vaccine Preventable Manuals (CDC)
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Q fever

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Rabies, human

• Disease Notes
• LHD Disease Investigation Steps
• Standing Order Template
• Case Definition
• Rabies prevention at summer camp (English, Spanish) (PDF)
• Disease Report Form
  • Part 1
  • Part 2

Rubella

• See Vaccine Preventable Manuals (CDC)
• Case Definition
• Disease Report Form
  • Part 1
  • Part 2
• Rubella Investigation Overview

Rubella, congenital

• See Vaccine Preventable Manuals (CDC)
• Case Definition
• Disease Report Form
• Part 1
• Part 2

S. aureus, reduced susceptibility to vancomycin

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Salmonellosis

• Disease Notes
• LHD Disease Investigation Steps
• Salmonella Foodborne Factsheet - NEW January 2019
• Case Definition - Updated January 2017
• Disease Report Form
• Part 1
• Part 2

SARS (coronavirus infection)

• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Shigellosis

• Disease Notes
• LHD Disease Investigation Steps
• Shigella Foodborne Factsheet - NEW January 2019
• Case Definition - Updated January 2017
• Disease Report Form
• Part 1
• Part 2
• Shigellosis Control Measures for Childcare Centers and K – 12 Schools - Updated July 2019

Smallpox

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Spotted Fever Rickettsiosis (Formerly RMSF)

• Disease Notes
• LHD Disease Investigation Steps - Updated January 2020
• Case Definition - Updated January 2020
• Disease Report Form
• Part 1
• Part 2
• Surveillance Algorithm

Streptococcal infection, Group A, invasive

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• Group A Strep Toolkit

Syphilis

• Disease Notes
• See Sexually Transmitted Disease Protocols
• Case Definition
• Disease Report Form

Tetanus

• See Vaccine Preventable Manuals (CDC)
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Toxic Shock Syndrome, non-streptococcal

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Toxic Shock Syndrome, streptococcal

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Trichinosis

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• Trichinosis Surveillance Case Report Form

Tuberculosis

• See Tuberculosis Policy Manual

Tularemia

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Typhoid Fever, acute

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• Typhoid and Paratyphoid Fever Surveillance Report Form

Typhoid, carriage

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Vaccinia

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2

Varicella (Chickenpox)

• Case Definition
• Disease Report Form
• Part 1
• Manual for the Surveillance of Vaccine-Preventable Diseases
• Varicella Investigation Overview (PDF)
• CDC Varicella Worksheet (PDF)
• Varicella Q and A (PDF)
• School Notification Example Letter (PDF, Word)

Vibrio infection (other than cholera & vulnificus)

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition - Updated January 2017
• Disease Report Form
• Part 1
• Part 2

Vibrio vulnificus infection

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition - Updated January 2017
• Disease Report Form
• Part 1
• Part 2

Yellow fever

• Disease Notes
• LHD Disease Investigation Steps
• Case Definition - Updated January 2020
• Disease Report Form
• Part 1
• Part 2

Zika

• LHD Disease Investigation Steps
• Case Definition
• Disease Report Form
• Part 1
• Part 2
• Current CDC Zika Testing Recommendations